| 1 | Main Title | James Horner | 2:28 |
| 2 | One Small Step | [dialogue] | 0:43 |
| 3 | Night Train | James Brown | 3:27 |
| 4 | Groovin' | The Young Rascals | 2:26 |
| 5 | Somebody to Love | Jefferson Airplane | 2:54 |
| 6 | I Can See for Miles | The Who | 4:09 |
| 7 | Purple Haze | Jimi Hendrix | 2:45 |
| 8 | Launch Control | [dialogue] | 0:31 |
| 9 | All Systems Go - The Launch | James Horner | 10:03 |
| 10 | Welcome to Apollo 13 | [dialogue] | 0:26 |
| 11 | Spirit in the Sky | Norman Greenbaum | 3:50 |
| 12 | House Cleaning / Houston, We Have a Problem | [dialogue] | 0:54 |
| 13 | Master Alarm | James Horner | 3:36 |
| 14 | What's Going On? | [dialogue] | 0:51 |
| 15 | Into the LEM | James Horner | 4:18 |
| 16 | Out of Time / Shut Her Down | [dialogue] | 0:33 |
| 17 | The Darkside of the Moon (feat. Annie Lennox) | James Horner | 4:49 |
| 18 | Failure Is Not an Option | [dialogue] | 0:23 |
| 19 | Honky Tonkin' | Hank Williams | 2:42 |
| 20 | Blue Moon | The Mavericks | 4:01 |
| 21 | Waiting for Disaster / A Privilege | [dialogue] | 0:29 |
| 22 | Re-Entry & Splashdown | James Horner | 8:52 |
| 23 | End Titles (feat. Annie Lennox) | James Horner | 7:01 |